ES8503329A1 - Un procedimiento para la preparacion de tetrahidro-benzo-(e)-isoindolinas. - Google Patents
Un procedimiento para la preparacion de tetrahidro-benzo-(e)-isoindolinas.Info
- Publication number
- ES8503329A1 ES8503329A1 ES522875A ES522875A ES8503329A1 ES 8503329 A1 ES8503329 A1 ES 8503329A1 ES 522875 A ES522875 A ES 522875A ES 522875 A ES522875 A ES 522875A ES 8503329 A1 ES8503329 A1 ES 8503329A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- hydrogen
- loweralkyl
- chem
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HNCVQRCXEUBSOQ-UHFFFAOYSA-N 2,3,3a,4,5,5a-hexahydro-1h-benzo[e]isoindole Chemical class C1=CC=CC2CCC3CNCC3=C21 HNCVQRCXEUBSOQ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- -1 benzyloxy, benzoyloxy, thiomethyl Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38363182A | 1982-06-01 | 1982-06-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES522875A0 ES522875A0 (es) | 1985-02-16 |
| ES8503329A1 true ES8503329A1 (es) | 1985-02-16 |
Family
ID=23514004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES522875A Expired ES8503329A1 (es) | 1982-06-01 | 1983-05-31 | Un procedimiento para la preparacion de tetrahidro-benzo-(e)-isoindolinas. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0095666B1 (en]) |
| JP (1) | JPS58225064A (en]) |
| KR (1) | KR900001193B1 (en]) |
| AT (1) | ATE40115T1 (en]) |
| AU (1) | AU560459B2 (en]) |
| CA (1) | CA1215376A (en]) |
| DE (1) | DE3378978D1 (en]) |
| ES (1) | ES8503329A1 (en]) |
| NZ (1) | NZ204213A (en]) |
| ZA (1) | ZA833494B (en]) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4622405A (en) * | 1984-07-25 | 1986-11-11 | Abbott Laboratories | 1,2,3,3a,8,8a-hexahydro-indeno[1,2-c]pyrroles useful in the treatment of hypertension |
| GR1001059B (el) * | 1988-12-15 | 1993-04-28 | Abbott Lab | Μεθοδος παραγωγης εκλεκτικων παραγοντων 5-ητ. |
| ES2090119T3 (es) * | 1988-12-15 | 1996-10-16 | Abbott Lab | Agentes selectivos de 5-ht. |
| FR2722194B1 (fr) * | 1994-07-06 | 1996-08-23 | Adir | Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent |
| US5792767A (en) * | 1995-01-27 | 1998-08-11 | Abbott Laboratories | Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists |
| ES2168682T3 (es) * | 1996-12-06 | 2002-06-16 | Abbott Lab | Compuestos alfa-1 adrenergicos a base de benzopiranopirrol y de benzopiranopiridina. |
| US5891882A (en) * | 1996-12-06 | 1999-04-06 | Abbott Laboratories | Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3166570A (en) * | 1963-02-15 | 1965-01-19 | American Home Prod | Derivatives of benzo[e] isoindoline and their preparation |
| EP0003757B1 (de) * | 1978-02-08 | 1981-10-14 | Ciba-Geigy Ag | Tricyclische Imidylderivate und Verfahren zu ihrer Herstellung |
| US4282240A (en) * | 1979-11-23 | 1981-08-04 | Merck & Co., Inc. | Amino substituted tetrahydrobenzindoles |
-
1983
- 1983-05-11 AU AU14452/83A patent/AU560459B2/en not_active Ceased
- 1983-05-12 NZ NZ204213A patent/NZ204213A/en unknown
- 1983-05-16 ZA ZA833494A patent/ZA833494B/xx unknown
- 1983-05-19 EP EP83104932A patent/EP0095666B1/en not_active Expired
- 1983-05-19 DE DE8383104932T patent/DE3378978D1/de not_active Expired
- 1983-05-19 AT AT83104932T patent/ATE40115T1/de not_active IP Right Cessation
- 1983-05-30 CA CA000429181A patent/CA1215376A/en not_active Expired
- 1983-05-31 ES ES522875A patent/ES8503329A1/es not_active Expired
- 1983-05-31 KR KR1019830002396A patent/KR900001193B1/ko not_active Expired
- 1983-05-31 JP JP58095088A patent/JPS58225064A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3378978D1 (de) | 1989-02-23 |
| EP0095666A2 (en) | 1983-12-07 |
| KR900001193B1 (ko) | 1990-02-28 |
| JPS58225064A (ja) | 1983-12-27 |
| ZA833494B (en) | 1984-02-29 |
| CA1215376A (en) | 1986-12-16 |
| JPH0443064B2 (en]) | 1992-07-15 |
| EP0095666B1 (en) | 1989-01-18 |
| ES522875A0 (es) | 1985-02-16 |
| ATE40115T1 (de) | 1989-02-15 |
| AU560459B2 (en) | 1987-04-09 |
| KR840005096A (ko) | 1984-11-03 |
| EP0095666A3 (en) | 1985-01-16 |
| AU1445283A (en) | 1983-12-08 |
| NZ204213A (en) | 1986-06-11 |
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